Drug interactions
Dronedarone + Perphenazine
Severity: Major
Dronedarone and Perphenazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, raising the likelihood of torsades de pointes. Perphenazine is also metabolized by CYP2D6, which dronedarone inhibits, potentially increasing perphenazine levels.
What this interaction means in plain words
Dronedarone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition by dronedarone raising perphenazine exposure.
What to do
Avoid the combination; if unavoidable, monitor ECG and electrolytes and use the lowest effective perphenazine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dronedarone with Perphenazine?
MediHelp rates the interaction as major. Dronedarone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, raising the likelihood of torsades de pointes. Perphenazine is also metabolized by CYP2D6, which dronedarone inhibits, potentially increasing perphenazine levels.
How serious is the interaction between Dronedarone and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, monitor ECG and electrolytes and use the lowest effective perphenazine dose.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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