Drug interactions
Dronedarone + Pomalidomide
Severity: Moderate
Dronedarone and Pomalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may modestly increase pomalidomide exposure as pomalidomide is a P-glycoprotein substrate. The clinical consequence is likely limited, with potential for increased myelosuppression.
What this interaction means in plain words
Dronedarone and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Pomalidomide belongs to Miscellaneous.
Why it happens
Dronedarone inhibits P-glycoprotein efflux, possibly raising pomalidomide levels.
What to do
Monitor blood counts regularly during coadministration and adjust pomalidomide dose for hematologic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Dronedarone with Pomalidomide?
MediHelp rates the interaction as moderate. Dronedarone and Pomalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may modestly increase pomalidomide exposure as pomalidomide is a P-glycoprotein substrate. The clinical consequence is likely limited, with potential for increased myelosuppression.
How serious is the interaction between Dronedarone and Pomalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly during coadministration and adjust pomalidomide dose for hematologic toxicity.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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