Drug interactions
Dronedarone + Rimegepant
Severity: Moderate
Dronedarone and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and may increase rimegepant exposure, which is a P-gp substrate. Higher levels may increase adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Dronedarone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Rimegepant belongs to Central Nervous System.
Why it happens
P-glycoprotein inhibition by dronedarone reduces rimegepant efflux and increases exposure.
What to do
Avoid a second rimegepant dose within 48 hours when given with a P-gp inhibitor, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Dronedarone with Rimegepant?
MediHelp rates the interaction as moderate. Dronedarone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits P-glycoprotein and may increase rimegepant exposure, which is a P-gp substrate. Higher levels may increase adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Dronedarone and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when given with a P-gp inhibitor, per labeling.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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