Drug interactions
Dronedarone + Trimethoprim
Severity: Moderate
Dronedarone and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim has been linked to QT prolongation and can cause hyperkalemia, while dronedarone prolongs QT. The combination may increase arrhythmia risk, though the evidence is limited.
What this interaction means in plain words
Dronedarone and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Additive effects on QT interval, with trimethoprim-induced hyperkalemia as a possible contributor.
What to do
Check potassium and obtain an ECG at baseline. Monitor QTc and electrolytes if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Dronedarone with Trimethoprim?
MediHelp rates the interaction as moderate. Dronedarone and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim has been linked to QT prolongation and can cause hyperkalemia, while dronedarone prolongs QT. The combination may increase arrhythmia risk, though the evidence is limited.
How serious is the interaction between Dronedarone and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and obtain an ECG at baseline. Monitor QTc and electrolytes if the combination is used.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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