Drug interactions
Dronedarone + Vemurafenib
Severity: Major
Dronedarone and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib causes QT prolongation and dronedarone shares this effect, increasing the risk of torsades de pointes. Dronedarone may also raise vemurafenib exposure through CYP3A4 or P-gp inhibition, while vemurafenib is a CYP3A4 inducer.
What this interaction means in plain words
Dronedarone and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible pharmacokinetic effects via CYP3A4 and P-gp.
What to do
Avoid the combination where possible. If used, monitor ECG and electrolytes before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Dronedarone with Vemurafenib?
MediHelp rates the interaction as major. Dronedarone and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib causes QT prolongation and dronedarone shares this effect, increasing the risk of torsades de pointes. Dronedarone may also raise vemurafenib exposure through CYP3A4 or P-gp inhibition, while vemurafenib is a CYP3A4 inducer.
How serious is the interaction between Dronedarone and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor ECG and electrolytes before and during treatment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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