Drug interactions
Drospirenone + Magnesium sulphate
Severity: Minor
Drospirenone and Magnesium sulphate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can modestly reduce renal magnesium loss, which could slightly raise serum magnesium. In patients receiving parenteral magnesium sulphate, particularly with renal impairment, this may add to the risk of magnesium accumulation. Clinical significance is usually small.
What this interaction means in plain words
Drospirenone and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Anti-mineralocorticoid effect of drospirenone may reduce renal magnesium excretion.
What to do
Monitor serum magnesium and deep tendon reflexes during magnesium sulphate infusion, especially if renal function is reduced. No dose change is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Magnesium sulphate?
MediHelp rates the interaction as minor. Drospirenone and Magnesium sulphate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has anti-mineralocorticoid activity and can modestly reduce renal magnesium loss, which could slightly raise serum magnesium. In patients receiving parenteral magnesium sulphate, particularly with renal impairment, this may add to the risk of magnesium accumulation. Clinical significance is usually small.
How serious is the interaction between Drospirenone and Magnesium sulphate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and deep tendon reflexes during magnesium sulphate infusion, especially if renal function is reduced. No dose change is normally needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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