Drug interactions
Droxidopa + Eletriptan
Severity: Moderate
Droxidopa and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise blood pressure, through vasoconstriction with eletriptan and norepinephrine formation with droxidopa. Together they may increase the risk of hypertension, particularly supine hypertension.
What this interaction means in plain words
Droxidopa and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Droxidopa belongs to Cardiovascular; Eletriptan belongs to Central Nervous System.
Why it happens
Additive pressor effects from triptan vasoconstriction and droxidopa conversion to norepinephrine.
What to do
Monitor blood pressure, including supine readings, when eletriptan is used in patients on droxidopa. Avoid dosing eletriptan close to bedtime and consider an alternative migraine treatment in patients with hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Methamphetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
Frequently asked questions
Can I take Droxidopa with Eletriptan?
MediHelp rates the interaction as moderate. Droxidopa and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise blood pressure, through vasoconstriction with eletriptan and norepinephrine formation with droxidopa. Together they may increase the risk of hypertension, particularly supine hypertension.
How serious is the interaction between Droxidopa and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, when eletriptan is used in patients on droxidopa. Avoid dosing eletriptan close to bedtime and consider an alternative migraine treatment in patients with hypertension.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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