Drug interactions
Dulaglutide + Insulin degludec-insulin aspart
Severity: Moderate
Dulaglutide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide added to insulin improves glycemic control but increases the risk of hypoglycemia. Insulin doses often need to be reduced when starting it.
What this interaction means in plain words
Dulaglutide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive glucose lowering: GLP-1 receptor agonism enhances glucose-dependent insulin secretion and suppresses glucagon, on top of exogenous insulin.
What to do
Consider lowering the insulin dose when starting dulaglutide and monitor blood glucose closely, adjusting as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide added to insulin improves glycemic control but increases the risk of hypoglycemia. Insulin doses often need to be reduced when starting it.
How serious is the interaction between Dulaglutide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting dulaglutide and monitor blood glucose closely, adjusting as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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