Drug interactions
Duloxetine + Dutasteride-tamsulosin
Severity: Moderate
Duloxetine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and may increase tamsulosin exposure. It can also cause orthostatic hypotension, so dizziness and falls may be more likely.
What this interaction means in plain words
Duloxetine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Duloxetine inhibits CYP2D6, reducing tamsulosin metabolism.
What to do
Monitor for orthostatic hypotension after starting or increasing duloxetine. Reduce the tamsulosin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Duloxetine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is a moderate CYP2D6 inhibitor and may increase tamsulosin exposure. It can also cause orthostatic hypotension, so dizziness and falls may be more likely.
How serious is the interaction between Duloxetine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension after starting or increasing duloxetine. Reduce the tamsulosin dose if symptoms develop.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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