Drug interactions
Duloxetine + Etodolac
Severity: Moderate
Duloxetine and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine combined with an NSAID increases the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with previous ulcers.
What this interaction means in plain words
Duloxetine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Etodolac belongs to Musculoskeletal.
Why it happens
Serotonin reuptake inhibition reduces platelet serotonin and aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor and monitor for signs of bleeding. Prefer a non-NSAID analgesic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Etodolac?
MediHelp rates the interaction as moderate. Duloxetine and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine combined with an NSAID increases the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with previous ulcers.
How serious is the interaction between Duloxetine and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor and monitor for signs of bleeding. Prefer a non-NSAID analgesic when feasible.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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