Drug interactions
Duloxetine + Gabapentin enacarbil
Severity: Moderate
Duloxetine and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which causes sedation, dizziness and respiratory depression, particularly with other CNS depressants. Duloxetine can also cause somnolence and dizziness, so the effects may add together and impair alertness and coordination.
What this interaction means in plain words
Duloxetine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective doses and titrate slowly. Monitor for sedation and, in patients with respiratory risk factors, for respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Duloxetine with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Duloxetine and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil is converted to gabapentin, which causes sedation, dizziness and respiratory depression, particularly with other CNS depressants. Duloxetine can also cause somnolence and dizziness, so the effects may add together and impair alertness and coordination.
How serious is the interaction between Duloxetine and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor for sedation and, in patients with respiratory risk factors, for respiratory depression.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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