Drug interactions
Duloxetine + Indomethacin
Severity: Moderate
Duloxetine and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, a serotonin-norepinephrine reuptake inhibitor, combined with indomethacin raises the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with prior GI bleeding.
What this interaction means in plain words
Duloxetine and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Indomethacin belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin impairs aggregation, adding to NSAID COX-1 inhibition and gastric mucosal injury.
What to do
Consider a proton pump inhibitor for at-risk patients or choose a non-NSAID analgesic. Monitor for GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Indomethacin?
MediHelp rates the interaction as moderate. Duloxetine and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, combined with indomethacin raises the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with prior GI bleeding.
How serious is the interaction between Duloxetine and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for at-risk patients or choose a non-NSAID analgesic. Monitor for GI bleeding signs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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