Drug interactions
Duloxetine + Ketoprofen
Severity: Major
Duloxetine and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, a serotonin-norepinephrine reuptake inhibitor, combined with an NSAID increases the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Duloxetine and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Ketoprofen belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin impairs aggregation, adding to NSAID antiplatelet effects and gastric mucosal injury.
What to do
Avoid if possible or use the lowest NSAID dose for the shortest time with a proton pump inhibitor in at-risk patients. Monitor for GI bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Ketoprofen?
MediHelp rates the interaction as major. Duloxetine and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, combined with an NSAID increases the risk of upper gastrointestinal bleeding.
How serious is the interaction between Duloxetine and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or use the lowest NSAID dose for the shortest time with a proton pump inhibitor in at-risk patients. Monitor for GI bleeding.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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