Drug interactions
Duloxetine + Lemborexant
Severity: Moderate
Duloxetine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic orexin antagonist and duloxetine may cause somnolence in some patients. Used together they may increase drowsiness and impair next-day alertness and psychomotor performance.
What this interaction means in plain words
Duloxetine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective lemborexant dose and warn the patient about next-day drowsiness and driving. Reduce the dose if daytime impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Duloxetine with Lemborexant?
MediHelp rates the interaction as moderate. Duloxetine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic orexin antagonist and duloxetine may cause somnolence in some patients. Used together they may increase drowsiness and impair next-day alertness and psychomotor performance.
How serious is the interaction between Duloxetine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and warn the patient about next-day drowsiness and driving. Reduce the dose if daytime impairment develops.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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