Drug interactions
Duloxetine + Leniolisib
Severity: Moderate
Duloxetine and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib may increase exposure to CYP1A2 substrates, and duloxetine is metabolized by CYP1A2. Higher duloxetine levels could increase adverse effects.
What this interaction means in plain words
Duloxetine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated duloxetine metabolism by leniolisib.
What to do
Monitor for duloxetine adverse effects such as nausea, dizziness and raised blood pressure, and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Duloxetine with Leniolisib?
MediHelp rates the interaction as moderate. Duloxetine and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib may increase exposure to CYP1A2 substrates, and duloxetine is metabolized by CYP1A2. Higher duloxetine levels could increase adverse effects.
How serious is the interaction between Duloxetine and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects such as nausea, dizziness and raised blood pressure, and reduce the dose if they occur.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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