Drug interactions
Duloxetine + Memantine-donepezil
Severity: Minor
Duloxetine and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and may increase donepezil exposure. This could add to cholinergic adverse effects such as nausea, bradycardia or syncope, though the effect is usually small.
What this interaction means in plain words
Duloxetine and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duloxetine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Duloxetine inhibits CYP2D6, reducing donepezil clearance.
What to do
Monitor heart rate and gastrointestinal tolerance after starting duloxetine; adjust the donepezil dose only if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Memantine-donepezil?
MediHelp rates the interaction as minor. Duloxetine and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine is a moderate CYP2D6 inhibitor and may increase donepezil exposure. This could add to cholinergic adverse effects such as nausea, bradycardia or syncope, though the effect is usually small.
How serious is the interaction between Duloxetine and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance after starting duloxetine; adjust the donepezil dose only if adverse effects emerge.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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