Drug interactions
Duloxetine + Naratriptan
Severity: Moderate
Duloxetine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a triptan and an SNRI may increase serotonergic activity and rarely lead to serotonin syndrome. The risk is low, and the combination is frequently used in patients with migraine and depression or pain.
What this interaction means in plain words
Duloxetine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from duloxetine reuptake inhibition and naratriptan 5-HT1B/1D agonism.
What to do
Educate the patient about serotonin syndrome symptoms and use the lowest effective triptan dose. Discontinue both agents and provide supportive care if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Duloxetine with Naratriptan?
MediHelp rates the interaction as moderate. Duloxetine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a triptan and an SNRI may increase serotonergic activity and rarely lead to serotonin syndrome. The risk is low, and the combination is frequently used in patients with migraine and depression or pain.
How serious is the interaction between Duloxetine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate the patient about serotonin syndrome symptoms and use the lowest effective triptan dose. Discontinue both agents and provide supportive care if toxicity is suspected.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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