Drug interactions
Duloxetine + Nebivolol
Severity: Moderate
Duloxetine and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate inhibitor of CYP2D6, the main enzyme that clears nebivolol. Nebivolol exposure can rise, which may deepen bradycardia and hypotension, especially in people who are already CYP2D6 poor metabolizers.
What this interaction means in plain words
Duloxetine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Duloxetine inhibits CYP2D6-mediated metabolism of nebivolol, raising its plasma concentrations.
What to do
Monitor heart rate and blood pressure when duloxetine is started, stopped or dose-changed. Reduce the nebivolol dose if symptomatic bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Nebivolol?
MediHelp rates the interaction as moderate. Duloxetine and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is a moderate inhibitor of CYP2D6, the main enzyme that clears nebivolol. Nebivolol exposure can rise, which may deepen bradycardia and hypotension, especially in people who are already CYP2D6 poor metabolizers.
How serious is the interaction between Duloxetine and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when duloxetine is started, stopped or dose-changed. Reduce the nebivolol dose if symptomatic bradycardia or hypotension develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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