Drug interactions
Duloxetine + Oliceridine
Severity: Major
Duloxetine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits CYP2D6, which contributes to oliceridine metabolism, so oliceridine exposure may increase and cause greater sedation and respiratory depression. Both drugs also have serotonergic activity, adding a possible risk of serotonin syndrome.
What this interaction means in plain words
Duloxetine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition by duloxetine plus additive serotonergic and CNS depressant effects.
What to do
Monitor closely for respiratory depression, sedation and serotonin syndrome, and titrate oliceridine to effect with lower or less frequent doses. Reassess the oliceridine dose if duloxetine is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Duloxetine with Oliceridine?
MediHelp rates the interaction as major. Duloxetine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duloxetine inhibits CYP2D6, which contributes to oliceridine metabolism, so oliceridine exposure may increase and cause greater sedation and respiratory depression. Both drugs also have serotonergic activity, adding a possible risk of serotonin syndrome.
How serious is the interaction between Duloxetine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression, sedation and serotonin syndrome, and titrate oliceridine to effect with lower or less frequent doses. Reassess the oliceridine dose if duloxetine is stopped.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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