Drug interactions
Duloxetine + Oxaprozin
Severity: Major
Duloxetine and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, a serotonin-norepinephrine reuptake inhibitor, increases bleeding risk and combined with an NSAID raises the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with ulcer history.
What this interaction means in plain words
Duloxetine and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Oxaprozin belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin impairs aggregation, adding to NSAID antiplatelet effect and gastric mucosal injury.
What to do
Avoid combination if possible; otherwise add a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Oxaprozin?
MediHelp rates the interaction as major. Duloxetine and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, increases bleeding risk and combined with an NSAID raises the risk of upper gastrointestinal bleeding. The risk is higher in older adults and those with ulcer history.
How serious is the interaction between Duloxetine and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if possible; otherwise add a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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