Drug interactions
Duloxetine + Oxymorphone
Severity: Moderate
Duloxetine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine moderately inhibits CYP2D6, but oxymorphone depends mainly on glucuronidation, so a pharmacokinetic effect is probably small. Both drugs have serotonergic or CNS effects, so additive sedation and rarely serotonin syndrome are possible.
What this interaction means in plain words
Duloxetine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Minor CYP2D6 inhibition plus additive serotonergic and CNS-depressant effects.
What to do
Monitor for sedation and for serotonin syndrome features such as agitation, tremor, hyperthermia and clonus, especially after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Oxymorphone?
MediHelp rates the interaction as moderate. Duloxetine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine moderately inhibits CYP2D6, but oxymorphone depends mainly on glucuronidation, so a pharmacokinetic effect is probably small. Both drugs have serotonergic or CNS effects, so additive sedation and rarely serotonin syndrome are possible.
How serious is the interaction between Duloxetine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for serotonin syndrome features such as agitation, tremor, hyperthermia and clonus, especially after dose changes.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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