Drug interactions
Duloxetine + Propafenone
Severity: Moderate
Duloxetine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is a moderate CYP2D6 inhibitor and can raise propafenone levels, while propafenone as a CYP2D6 inhibitor can raise duloxetine levels. Increased propafenone exposure raises the risk of conduction abnormalities and arrhythmia, and higher duloxetine exposure may increase adverse effects such as nausea and blood pressure rises.
What this interaction means in plain words
Duloxetine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Mutual inhibition of CYP2D6-mediated metabolism.
What to do
Monitor ECG and heart rate when combining, and reduce propafenone dose if QRS widening or bradycardia occurs. Watch for duloxetine adverse effects and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Duloxetine and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Propafenone?
MediHelp rates the interaction as moderate. Duloxetine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is a moderate CYP2D6 inhibitor and can raise propafenone levels, while propafenone as a CYP2D6 inhibitor can raise duloxetine levels. Increased propafenone exposure raises the risk of conduction abnormalities and arrhythmia, and higher duloxetine exposure may increase adverse effects such as nausea and blood pressure rises.
How serious is the interaction between Duloxetine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when combining, and reduce propafenone dose if QRS widening or bradycardia occurs. Watch for duloxetine adverse effects and adjust the dose accordingly.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
