Drug interactions
Duloxetine + Ritonavir
Severity: Moderate
Duloxetine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and CYP3A4 but also induces CYP1A2 with prolonged use, so net effects on duloxetine are unpredictable. Higher exposure with side effects or reduced efficacy are both possible.
What this interaction means in plain words
Duloxetine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP2D6 while inducing CYP1A2, producing variable change in duloxetine clearance.
What to do
Monitor clinical response and tolerability when ritonavir is started or stopped. Adjust the duloxetine dose based on effect and adverse events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Duloxetine with Ritonavir?
MediHelp rates the interaction as moderate. Duloxetine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and CYP3A4 but also induces CYP1A2 with prolonged use, so net effects on duloxetine are unpredictable. Higher exposure with side effects or reduced efficacy are both possible.
How serious is the interaction between Duloxetine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability when ritonavir is started or stopped. Adjust the duloxetine dose based on effect and adverse events.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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