Drug interactions
Duloxetine + Sulindac
Severity: Moderate
Duloxetine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, a serotonin and norepinephrine reuptake inhibitor, increases bleeding risk when combined with NSAIDs, especially in the upper gastrointestinal tract. Risk is higher in older patients and those with ulcer history.
What this interaction means in plain words
Duloxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin uptake impairs aggregation, adding to NSAID platelet inhibition and gastric mucosal injury.
What to do
Consider a proton pump inhibitor in at-risk patients and monitor for signs of GI bleeding. Use the lowest effective NSAID dose briefly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Sulindac?
MediHelp rates the interaction as moderate. Duloxetine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine, a serotonin and norepinephrine reuptake inhibitor, increases bleeding risk when combined with NSAIDs, especially in the upper gastrointestinal tract. Risk is higher in older patients and those with ulcer history.
How serious is the interaction between Duloxetine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and monitor for signs of GI bleeding. Use the lowest effective NSAID dose briefly.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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