Drug interactions
Duloxetine + Tolfenamic acid
Severity: Moderate
Duloxetine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine reduces platelet serotonin and tolfenamic acid, an NSAID, inhibits platelet function and irritates the gastric mucosa. Combined use increases the risk of upper gastrointestinal bleeding.
What this interaction means in plain words
Duloxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis: SNRI platelet serotonin depletion plus NSAID COX inhibition and mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in patients at risk. Advise patients to report melena or other bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Duloxetine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Duloxetine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine reduces platelet serotonin and tolfenamic acid, an NSAID, inhibits platelet function and irritates the gastric mucosa. Combined use increases the risk of upper gastrointestinal bleeding.
How serious is the interaction between Duloxetine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider a proton pump inhibitor in patients at risk. Advise patients to report melena or other bleeding.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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