Drug interactions
Dupilumab + Quinidine
Severity: Minor
Dupilumab and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab may normalize cytokine-suppressed CYP450 enzyme activity in patients with chronic inflammation, which could alter the clearance of quinidine. Any effect is theoretical and likely small.
What this interaction means in plain words
Dupilumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dupilumab belongs to Respiratory; Quinidine belongs to Anti Parasitic.
Why it happens
Reversal of cytokine-mediated CYP suppression after dupilumab treatment of inflammatory disease.
What to do
Consider monitoring quinidine levels and ECG when dupilumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Dupilumab
Frequently asked questions
Can I take Dupilumab with Quinidine?
MediHelp rates the interaction as minor. Dupilumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dupilumab may normalize cytokine-suppressed CYP450 enzyme activity in patients with chronic inflammation, which could alter the clearance of quinidine. Any effect is theoretical and likely small.
How serious is the interaction between Dupilumab and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider monitoring quinidine levels and ECG when dupilumab is started or stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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