Drug interactions
Dutasteride-tamsulosin + Fedratinib
Severity: Moderate
Dutasteride-tamsulosin and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin. Exposure to tamsulosin may rise, increasing the risk of dizziness, orthostatic hypotension and syncope. Dutasteride is also a CYP3A4 substrate, though its slow elimination makes the effect less relevant.
What this interaction means in plain words
Dutasteride-tamsulosin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4 and CYP2D6, reducing the metabolic clearance of tamsulosin.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at the start of fedratinib therapy. Reduce the tamsulosin dose or stop it if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dutasteride-tamsulosin with Fedratinib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, the two main enzymes that clear tamsulosin. Exposure to tamsulosin may rise, increasing the risk of dizziness, orthostatic hypotension and syncope. Dutasteride is also a CYP3A4 substrate, though its slow elimination makes the effect less relevant.
How serious is the interaction between Dutasteride-tamsulosin and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at the start of fedratinib therapy. Reduce the tamsulosin dose or stop it if symptomatic hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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