Drug interactions
Dutasteride-tamsulosin + Fluconazole
Severity: Moderate
Dutasteride-tamsulosin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor (and CYP2C9/2C19 inhibitor) and can raise tamsulosin and dutasteride levels. Increased tamsulosin exposure may cause dizziness and orthostatic hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing metabolism of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension, particularly with higher fluconazole doses or prolonged courses. Reduce the tamsulosin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Fluconazole?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor (and CYP2C9/2C19 inhibitor) and can raise tamsulosin and dutasteride levels. Increased tamsulosin exposure may cause dizziness and orthostatic hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension, particularly with higher fluconazole doses or prolonged courses. Reduce the tamsulosin dose if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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