Drug interactions
Duvelisib + Eletriptan
Severity: Moderate
Duvelisib and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can increase exposure to eletriptan, a sensitive CYP3A4 substrate. Higher eletriptan levels may increase adverse effects such as vasoconstriction, hypertension and chest symptoms.
What this interaction means in plain words
Duvelisib and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Eletriptan belongs to Central Nervous System.
Why it happens
Duvelisib inhibits CYP3A4-mediated eletriptan metabolism.
What to do
Consider using a lower eletriptan dose or a triptan not metabolised by CYP3A4, and monitor for adverse effects. Note that strong CYP3A4 inhibitors are contraindicated with eletriptan within a defined period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Eletriptan?
MediHelp rates the interaction as moderate. Duvelisib and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can increase exposure to eletriptan, a sensitive CYP3A4 substrate. Higher eletriptan levels may increase adverse effects such as vasoconstriction, hypertension and chest symptoms.
How serious is the interaction between Duvelisib and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider using a lower eletriptan dose or a triptan not metabolised by CYP3A4, and monitor for adverse effects. Note that strong CYP3A4 inhibitors are contraindicated with eletriptan within a defined period.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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