Drug interactions
Duvelisib + Everolimus
Severity: Moderate
Duvelisib and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase everolimus exposure, with greater risk of stomatitis, infection, pneumonitis and metabolic effects. Both drugs have overlapping infection and pneumonitis risks.
What this interaction means in plain words
Duvelisib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Everolimus belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing everolimus metabolism.
What to do
Monitor for everolimus toxicity and everolimus trough concentrations where available; reduce the everolimus dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Everolimus?
MediHelp rates the interaction as moderate. Duvelisib and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase everolimus exposure, with greater risk of stomatitis, infection, pneumonitis and metabolic effects. Both drugs have overlapping infection and pneumonitis risks.
How serious is the interaction between Duvelisib and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for everolimus toxicity and everolimus trough concentrations where available; reduce the everolimus dose if adverse effects occur.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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