Drug interactions
Duvelisib + Palbociclib
Severity: Moderate
Duvelisib and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase palbociclib exposure, which could worsen neutropenia and other palbociclib toxicities. Duvelisib itself carries infection and myelosuppression risks, so overlapping toxicity is a concern.
What this interaction means in plain words
Duvelisib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Palbociclib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing the clearance of palbociclib.
What to do
Monitor blood counts frequently for neutropenia and infection, and reduce the palbociclib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Palbociclib?
MediHelp rates the interaction as moderate. Duvelisib and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase palbociclib exposure, which could worsen neutropenia and other palbociclib toxicities. Duvelisib itself carries infection and myelosuppression risks, so overlapping toxicity is a concern.
How serious is the interaction between Duvelisib and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts frequently for neutropenia and infection, and reduce the palbociclib dose if toxicity develops.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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