Drug interactions
Duvelisib + Ranolazine
Severity: Major
Duvelisib and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to ranolazine, a CYP3A4 substrate, increasing dizziness, nausea and QT prolongation. Ranolazine may also modestly increase duvelisib through P-gp inhibition.
What this interaction means in plain words
Duvelisib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duvelisib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by duvelisib reduces ranolazine metabolism, with additional P-glycoprotein effects.
What to do
Reduce the ranolazine dose and monitor for adverse effects and QTc. Monitor for duvelisib toxicity such as infection, diarrhea and skin reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Ranolazine?
MediHelp rates the interaction as major. Duvelisib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise exposure to ranolazine, a CYP3A4 substrate, increasing dizziness, nausea and QT prolongation. Ranolazine may also modestly increase duvelisib through P-gp inhibition.
How serious is the interaction between Duvelisib and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ranolazine dose and monitor for adverse effects and QTc. Monitor for duvelisib toxicity such as infection, diarrhea and skin reactions.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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