Drug interactions
Duvelisib + Ruxolitinib
Severity: Moderate
Duvelisib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise ruxolitinib exposure. This increases risks of cytopenias and infection, which are also seen with duvelisib.
What this interaction means in plain words
Duvelisib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by duvelisib reduces ruxolitinib clearance, with additive immunosuppression.
What to do
Monitor blood counts and infection signs closely, and consider reducing the ruxolitinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Ruxolitinib?
MediHelp rates the interaction as moderate. Duvelisib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise ruxolitinib exposure. This increases risks of cytopenias and infection, which are also seen with duvelisib.
How serious is the interaction between Duvelisib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs closely, and consider reducing the ruxolitinib dose.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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