Drug interactions
Duvelisib + Trazodone
Severity: Moderate
Duvelisib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive substrates such as trazodone. Higher trazodone levels may cause excessive sedation, orthostatic hypotension, dizziness and QT effects.
What this interaction means in plain words
Duvelisib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Duvelisib inhibits CYP3A4-mediated metabolism of trazodone.
What to do
Consider reducing the trazodone dose and monitor for sedation, hypotension and arrhythmia symptoms. Adjust the dose again when duvelisib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Trazodone?
MediHelp rates the interaction as moderate. Duvelisib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive substrates such as trazodone. Higher trazodone levels may cause excessive sedation, orthostatic hypotension, dizziness and QT effects.
How serious is the interaction between Duvelisib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the trazodone dose and monitor for sedation, hypotension and arrhythmia symptoms. Adjust the dose again when duvelisib is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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