Drug interactions
Duvelisib + Trimipramine
Severity: Moderate
Duvelisib and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase trimipramine exposure. This can increase sedation, anticholinergic effects and cardiac toxicity.
What this interaction means in plain words
Duvelisib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of trimipramine.
What to do
Monitor for tricyclic toxicity and consider lowering the trimipramine dose. Obtain an ECG if symptoms of toxicity develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Trimipramine?
MediHelp rates the interaction as moderate. Duvelisib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may increase trimipramine exposure. This can increase sedation, anticholinergic effects and cardiac toxicity.
How serious is the interaction between Duvelisib and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider lowering the trimipramine dose. Obtain an ECG if symptoms of toxicity develop.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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