Drug interactions
Edoxaban + Eliglustat
Severity: Moderate
Edoxaban and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise edoxaban concentrations, increasing the chance of bleeding. Exposure change is predicted from mechanism.
What this interaction means in plain words
Edoxaban and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits P-glycoprotein, reducing edoxaban efflux and clearance.
What to do
Monitor for bleeding, and consider the 30 mg daily dose when treating DVT/PE. No reduction is recommended for atrial fibrillation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Edoxaban with Eliglustat?
MediHelp rates the interaction as moderate. Edoxaban and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and may raise edoxaban concentrations, increasing the chance of bleeding. Exposure change is predicted from mechanism.
How serious is the interaction between Edoxaban and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, and consider the 30 mg daily dose when treating DVT/PE. No reduction is recommended for atrial fibrillation.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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