Drug interactions
Edoxaban + Etravirine
Severity: Moderate
Edoxaban and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine has weak P-glycoprotein inhibitory activity and might modestly raise edoxaban levels. Clinical significance is uncertain but bleeding risk could increase.
What this interaction means in plain words
Edoxaban and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Etravirine belongs to Anti Virals.
Why it happens
Possible P-glycoprotein inhibition by etravirine increases edoxaban exposure.
What to do
Monitor for bleeding signs and renal function; dose reduction is generally not needed unless other P-gp inhibitors or renal impairment are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Edoxaban with Etravirine?
MediHelp rates the interaction as moderate. Edoxaban and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine has weak P-glycoprotein inhibitory activity and might modestly raise edoxaban levels. Clinical significance is uncertain but bleeding risk could increase.
How serious is the interaction between Edoxaban and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and renal function; dose reduction is generally not needed unless other P-gp inhibitors or renal impairment are present.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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