Drug interactions
Edoxaban + Fluvoxamine
Severity: Moderate
Edoxaban and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine reduces platelet serotonin stores and aggregation, which can increase bleeding when given with edoxaban. The clinical risk is mainly of mucosal and GI bleeding.
What this interaction means in plain words
Edoxaban and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SSRI-related platelet dysfunction plus factor Xa inhibition.
What to do
Monitor for bleeding and anemia during co-therapy. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Edoxaban with Fluvoxamine?
MediHelp rates the interaction as moderate. Edoxaban and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine reduces platelet serotonin stores and aggregation, which can increase bleeding when given with edoxaban. The clinical risk is mainly of mucosal and GI bleeding.
How serious is the interaction between Edoxaban and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and anemia during co-therapy. Consider gastroprotection in high-risk patients.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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