Drug interactions
Edoxaban + Ivacaftor
Severity: Minor
Edoxaban and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a weak P-gp inhibitor and may increase edoxaban exposure modestly. The clinical consequence is likely small but bleeding risk could rise in susceptible patients.
What this interaction means in plain words
Edoxaban and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak inhibition of P-glycoprotein reduces edoxaban efflux.
What to do
No routine dose adjustment is needed; monitor for bleeding, especially with renal impairment or low body weight.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Edoxaban with Ivacaftor?
MediHelp rates the interaction as minor. Edoxaban and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a weak P-gp inhibitor and may increase edoxaban exposure modestly. The clinical consequence is likely small but bleeding risk could rise in susceptible patients.
How serious is the interaction between Edoxaban and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor for bleeding, especially with renal impairment or low body weight.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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