Drug interactions
Edoxaban + Liposomal doxorubicin
Severity: Minor
Edoxaban and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a P-glycoprotein substrate and has weak inhibitory activity at best, and it is not recognized as a P-gp inducer. A meaningful reduction in edoxaban levels is not expected, although cancer-related thrombocytopenia may complicate anticoagulation.
What this interaction means in plain words
Edoxaban and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Liposomal doxorubicin belongs to Oncology.
Why it happens
No established pharmacokinetic interaction; doxorubicin is not a P-gp inducer.
What to do
No dose adjustment is needed for the interaction; monitor platelet counts and bleeding risk during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Edoxaban and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is a P-glycoprotein substrate and has weak inhibitory activity at best, and it is not recognized as a P-gp inducer. A meaningful reduction in edoxaban levels is not expected, although cancer-related thrombocytopenia may complicate anticoagulation.
How serious is the interaction between Edoxaban and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for the interaction; monitor platelet counts and bleeding risk during chemotherapy.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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