Drug interactions
Edoxaban + Lomitapide
Severity: Moderate
Edoxaban and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may increase edoxaban concentrations, raising bleeding risk. Data specific to edoxaban are lacking.
What this interaction means in plain words
Edoxaban and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein, increasing edoxaban absorption.
What to do
Monitor for bleeding; consider separating doses and the reduced edoxaban dose for DVT/PE.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Edoxaban with Lomitapide?
MediHelp rates the interaction as moderate. Edoxaban and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may increase edoxaban concentrations, raising bleeding risk. Data specific to edoxaban are lacking.
How serious is the interaction between Edoxaban and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding; consider separating doses and the reduced edoxaban dose for DVT/PE.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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