Drug interactions
Edoxaban + Lonafarnib
Severity: Minor
Edoxaban and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib weakly inhibits P-gp and may modestly raise edoxaban exposure. This could increase bleeding risk, particularly in patients with renal impairment.
What this interaction means in plain words
Edoxaban and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits P-glycoprotein, reducing edoxaban efflux.
What to do
Monitor for bleeding and renal function. No routine dose change is needed unless bleeding develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Edoxaban with Lonafarnib?
MediHelp rates the interaction as minor. Edoxaban and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib weakly inhibits P-gp and may modestly raise edoxaban exposure. This could increase bleeding risk, particularly in patients with renal impairment.
How serious is the interaction between Edoxaban and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. No routine dose change is needed unless bleeding develops.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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