Drug interactions
Edoxaban + Mefloquine
Severity: Moderate
Edoxaban and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine is a P-glycoprotein inhibitor and may raise edoxaban exposure, increasing the risk of bleeding. The effect is likely modest compared with potent P-gp inhibitors.
What this interaction means in plain words
Edoxaban and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of edoxaban, increasing its absorption and reducing clearance.
What to do
Monitor for signs of bleeding and check renal function. Consider a dose reduction only if edoxaban labeling for P-gp inhibitors applies to the indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Mefloquine?
MediHelp rates the interaction as moderate. Edoxaban and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine is a P-glycoprotein inhibitor and may raise edoxaban exposure, increasing the risk of bleeding. The effect is likely modest compared with potent P-gp inhibitors.
How serious is the interaction between Edoxaban and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check renal function. Consider a dose reduction only if edoxaban labeling for P-gp inhibitors applies to the indication.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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