Drug interactions
Edoxaban + Tacrolimus
Severity: Moderate
Edoxaban and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit P-glycoprotein and modestly raise edoxaban exposure, with possible increased bleeding. Renal impairment from tacrolimus can further increase edoxaban levels.
What this interaction means in plain words
Edoxaban and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition increases edoxaban absorption; nephrotoxicity may reduce edoxaban elimination.
What to do
Monitor renal function and for bleeding; adjust edoxaban dose if creatinine clearance falls into a range requiring reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Edoxaban with Tacrolimus?
MediHelp rates the interaction as moderate. Edoxaban and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may inhibit P-glycoprotein and modestly raise edoxaban exposure, with possible increased bleeding. Renal impairment from tacrolimus can further increase edoxaban levels.
How serious is the interaction between Edoxaban and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for bleeding; adjust edoxaban dose if creatinine clearance falls into a range requiring reduction.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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