Drug interactions
Edoxaban + Tipranavir
Severity: Major
Edoxaban and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir has mixed P-gp effects, with net induction on chronic dosing, so edoxaban levels might fall. Reduced anticoagulant effect could lead to thrombosis, though data are limited.
What this interaction means in plain words
Edoxaban and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir-associated P-glycoprotein induction may reduce edoxaban absorption, although initial inhibition by ritonavir may transiently increase it.
What to do
Avoid the combination if possible and use an alternative anticoagulant. If used, monitor for both thrombotic and bleeding events.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Edoxaban with Tipranavir?
MediHelp rates the interaction as major. Edoxaban and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir with ritonavir has mixed P-gp effects, with net induction on chronic dosing, so edoxaban levels might fall. Reduced anticoagulant effect could lead to thrombosis, though data are limited.
How serious is the interaction between Edoxaban and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative anticoagulant. If used, monitor for both thrombotic and bleeding events.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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