Drug interactions
Efavirenz + Elagolix
Severity: Moderate
Efavirenz and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz, a CYP3A4 inducer, can reduce elagolix concentrations and efficacy, while elagolix as a weak-to-moderate inducer may lower efavirenz levels. Reduced efficacy of either drug is possible.
What this interaction means in plain words
Efavirenz and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Elagolix belongs to Musculoskeletal.
Why it happens
Mutual CYP3A4 induction.
What to do
Monitor endometriosis or fibroid symptom control and HIV viral load. Consider alternative therapy if elagolix response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Efavirenz with Elagolix?
MediHelp rates the interaction as moderate. Efavirenz and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz, a CYP3A4 inducer, can reduce elagolix concentrations and efficacy, while elagolix as a weak-to-moderate inducer may lower efavirenz levels. Reduced efficacy of either drug is possible.
How serious is the interaction between Efavirenz and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor endometriosis or fibroid symptom control and HIV viral load. Consider alternative therapy if elagolix response is inadequate.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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