Drug interactions
Efavirenz + Medroxyprogesterone
Severity: Moderate
Efavirenz and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower medroxyprogesterone levels, though injectable depot contraception appears to retain efficacy. Oral forms may be less reliable.
What this interaction means in plain words
Efavirenz and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Medroxyprogesterone belongs to Endocrine.
Why it happens
CYP3A4 induction increases medroxyprogesterone metabolism.
What to do
For contraception, depot medroxyprogesterone can generally be continued on the usual schedule. For oral use, consider a higher dose or an additional barrier method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Efavirenz with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Efavirenz and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower medroxyprogesterone levels, though injectable depot contraception appears to retain efficacy. Oral forms may be less reliable.
How serious is the interaction between Efavirenz and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For contraception, depot medroxyprogesterone can generally be continued on the usual schedule. For oral use, consider a higher dose or an additional barrier method.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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