Drug interactions
Efavirenz + Perampanel
Severity: Moderate
Efavirenz and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel is metabolized mainly by CYP3A4, and efavirenz can lower its concentrations, which may weaken seizure control. Enzyme-inducing drugs substantially shorten perampanel half-life.
What this interaction means in plain words
Efavirenz and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Perampanel belongs to Central Nervous System.
Why it happens
CYP3A4 induction by efavirenz increases perampanel clearance.
What to do
Monitor seizure frequency and titrate perampanel to clinical response. Reduce the dose again if efavirenz is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Efavirenz with Perampanel?
MediHelp rates the interaction as moderate. Efavirenz and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel is metabolized mainly by CYP3A4, and efavirenz can lower its concentrations, which may weaken seizure control. Enzyme-inducing drugs substantially shorten perampanel half-life.
How serious is the interaction between Efavirenz and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and titrate perampanel to clinical response. Reduce the dose again if efavirenz is stopped.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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