Drug interactions
Efavirenz + Prochlorperazine
Severity: Moderate
Efavirenz and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease. Efavirenz also causes CNS effects that may add to phenothiazine sedation.
What this interaction means in plain words
Efavirenz and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation; efavirenz CNS effects may add to phenothiazine effects.
What to do
Correct potassium and magnesium before use and obtain a baseline ECG in at-risk patients. Monitor for palpitations, syncope and excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Prochlorperazine?
MediHelp rates the interaction as moderate. Efavirenz and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbance or heart disease. Efavirenz also causes CNS effects that may add to phenothiazine sedation.
How serious is the interaction between Efavirenz and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before use and obtain a baseline ECG in at-risk patients. Monitor for palpitations, syncope and excess sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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