Drug interactions
Efavirenz + Ticlopidine
Severity: Moderate
Efavirenz and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2B6 and could raise efavirenz levels, increasing CNS adverse effects. Efavirenz may also reduce ticlopidine activation, though clinical data are lacking.
What this interaction means in plain words
Efavirenz and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2B6-mediated efavirenz metabolism, while efavirenz may alter CYP-dependent ticlopidine bioactivation.
What to do
Monitor for efavirenz CNS toxicity and platelet response. Consider an alternative antiplatelet, since ticlopidine is rarely used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ticlopidine
Frequently asked questions
Can I take Efavirenz with Ticlopidine?
MediHelp rates the interaction as moderate. Efavirenz and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2B6 and could raise efavirenz levels, increasing CNS adverse effects. Efavirenz may also reduce ticlopidine activation, though clinical data are lacking.
How serious is the interaction between Efavirenz and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for efavirenz CNS toxicity and platelet response. Consider an alternative antiplatelet, since ticlopidine is rarely used.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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